Neuraxial Dexmedetomidine: Wonder Drug or Simply Harmful

Neuraxial Dexmedetomidine: Wonder Drug or Simply Harmful

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. In ...

neuraxial dexmedetomidine: wonder drug or simply harmful

Imatinib for Pulmonary Arterial Hypertension - Wonder Drug or Killer Drug?

tinib showed significant improvement in hemodynamics and physical capacity after 24 months of therapy [7] . Based on these data and independent of any interests on the part of the pharmaceutical industry, pulmonary hypertension specialists in several countries have offered open-label imatinib to their PAH patients as a palliative treatment, but, unfortunately, with little in the way of publishe...

Penicillin: The Old/New Wonder Drug

Although it was discovered in 1928 by Alexander Fleming, a microbiologist at St. Mary’s Hospital in London, penicillin languished for more than a decade before its importance was noticed. As its antimicrobial properties became more apparent, large enough quantities were produced for clinical trials through the efforts of Florey et al. [1]. Then came World War II, and the U.S. government became ...

Nesiritide: harmful or harmless?

Nesiritide is the recombinant form of human B-type (brain) natriuretic peptide (BNP), and its amino acid sequence is identical to that of endogenous human BNP. Administration of nesiritide results in venous and arterial vasodilation, as well as enhanced diuresis. Given the many limitations of therapies previously available for the treatment of acute decompensated heart failure, the anticipation...